There's a famous story that after R' Yaakov Kamenetsky saw the moon landing, he declared Maimonides wrong. Some people like this story because they think it shows that the gedolim of yesteryear were open to scientific discovery. Others like it because Maimonides, the sage who relied on secular thought for his understanding of the universe, was wrong; therefore, secular studies are worthless and we should rely on the Torah and the gedolim who understand it to tell us about the natural world. R' Yaakov himself begs this line of reasoning: "...we saw men descending from a space ship on a ladder onto the surface of the moon. I thought to myself: 'What would the Rambam, who wrote that the moon has a spiritual form, answer now?' Kabbalah defeated Philosophy, and comforted myself with the words of the Ramban...[Rambam] wrote those four chapters from his deep mind and from his knowledge of secular wisdom, i.e. not from the wisdom of Torah but only from Philosophy." (R' Gil's translation)
Both of these ideas strike me as extremely stupid. With regards to the first line of reasoning: It took R' Yaakov Kamenetsky till they landed on the moon for him to declare Maimonides wrong? Seriously? That's called openness to science? Yeah, sure, it's more open than declaring the moon landing a hoax, but it's still a very fundamentalist mode.
As for the second: Ramban lived in a world where magic was a real historical force. One of my two favorite conscientiousness-raising exercises actually relates to one of Ramban's ideas. Sometimes, with regards to some "controversial" idea or another (e.g. the position of many that Chazal were wrong about science), people wave their hands, laugh, and say, "We don't hold like those rishonim!" I ask them if they believe that astrology has worked at some point (an idea unsurprisingly maintained by many, including Ramban) and they usually answer is in the affirmative. I then ask them about Rambam, who maintained that astrology is "stupidity." They reply, "I'd think it obvious! We don't hold like that Rambam!" I then point out, well, that's fine; but just so they know, the Rambam thinks the position they maintain is idiotic.
I hold like the Rambam on this issue.